Artificial intelligence (AI) is revolutionizing healthcare across the globe, and nowhere is this more evident than in the emerging ecosystem of Sharjah and the established hub of Seattle. While Sharjah is leveraging government strategy, investment funds, and infrastructure to nurture AI health-tech startups, Seattle thrives on its mature technology scene, clinical expertise, and innovation-driven culture. This article explores how AI is transforming healthcare startups in both regions, the role of mobile app development firms, cross-border collaboration, and strategies for building impactful AI-powered health solutions.